Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induced Loss of ADAR2 Engenders Slow Death of Motor Neurons from Q/R Site-Unedited GluR2

8 Sept 2010

Abstract excerpt

GluR2 is a subunit of the AMPA receptor, and the adenosine for the Q/R site of its pre-mRNA is converted to inosine (A-to-I conversion) by the enzyme called adenosine deaminase acting on RNA 2 (ADAR2). Failure of A-to-I conversion at this site affects multiple AMPA receptor properties, including the Ca(2+) permeability of the receptor-coupled ion channel, thereby inducing fatal epilepsy in mice (Brusa et al.,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA regulation and disease
Share to RNA Research and Splicing
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20826656
DOI: 10.1523/jneurosci.2021-10.2010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induced Loss of ADAR2 Engenders Slow Death of Motor Neurons from Q/R Site-Unedited GluR2PMID 20826656Read ↗

When Does ALS Start? ADAR2?GluA2 Hypothesis for the Etiology of Sporadic ALSSemantic proximity Read ↗

The AMPA receptor antagonist perampanel robustly rescues amyotrophic lateral sclerosis (ALS) pathology in sporadic ALS model mice.Semantic proximity Read ↗

Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9‐ADAR2 delivery to motor neuronsSemantic proximity Read ↗

The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s diseaseSemantic proximity Read ↗

GluR2 Deficiency Accelerates Motor Neuron Degeneration in a Mouse Model of Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Co-Occurrence of TDP-43 Mislocalization with Reduced Activity of an RNA Editing Enzyme, ADAR2, in Aged Mouse Motor NeuronsSemantic proximity Read ↗

Novel ADAR2 variants in children with seizures, intellectual disability, and motor delay have reduced RNA editing.Semantic proximity Read ↗

Transgenic rescue for characterizing orphan receptors: a review of delta2 glutamate receptor.Semantic proximity Read ↗

Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice.Semantic proximity Read ↗

Underediting of GluR2 mRNA, a neuronal death inducing molecular change in sporadic ALS, does not occur in motor neurons in ALS1 or SBMA.Semantic proximity Read ↗

The AMPA receptor subunit GluR-B in its Q/R site-unedited form is not essential for brain development and function.Semantic proximity Read ↗

[ALS and excitatory amino acid].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.