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Article

Dysfunctions in mice by NMDA receptor point mutations NR1(N598Q) and NR1(N598R).

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Apr 2000

Single F N, Rozov A, Burnashev N, Zimmermann F, Hanley D F, Forrest D, Curran T, Jensen V, Hvalby O, Sprengel R, Seeburg P H

Abstract excerpt

NMDA receptors in mice were mutated by gene targeting to substitute asparagine (N) in position 598 of the NR1 subunit to glutamine (Q) or arginine (R). Animals expressing exclusively the mutated NR1 alleles, NR1(Q/Q) and NR1(-/R) mice, developed a perinatally lethal phenotype mainly characterized by respiratory failure. The dysfunctions were partially rescued in heterozygous mice by the presence of pure wild-type...

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PMID: 10729336
PMCID: PMC6772252

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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