Article
Structural basis for recognition of the matrix attachment region of DNA by transcription factor SATB1.
Nucleic acids research - 1 Jan 2007
Yamasaki Kazuhiko, Akiba Toshihiko, Yamasaki Tomoko, Harata Kazuaki
Abstract excerpt
Special AT-rich sequence binding protein 1 (SATB1) regulates gene expression essential in immune T-cell maturation and switching of fetal globin species, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin remodeling. Previously we have revealed a five-helix structure of the N-terminal CUT domain, which is essentially the folded region in the MAR-binding domain, of human SATB1 by...
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