Mutations in topA interfere with the inducible expression of DNA damage response loci in Salmonella typhimurium.

doi:10.1002/em.2850190302

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Article

Mutations in topA interfere with the inducible expression of DNA damage response loci in Salmonella typhimurium.

Environmental and molecular mutagenesis - 1 Jan 1992

Smith C M, Arany Z, Orrego C, Eisenstadt E

Abstract excerpt

Strains of Salmonella typhimurium deficient in topoisomerase I activity (topA mutants) are UV sensitive and non-mutable (Overbye and Margolin: J Bacteriol 146:170-178, 1981). Using lac-operon fusions to DNA damage inducible (din) loci we investigated whether these observations could be explained...

Topics

Bacterial Proteins
DNA Damage
DNA Helicases
DNA Topoisomerases, Type I
DNA, Superhelical
Escherichia coli Proteins
Kinetics
Lac Operon
Mutation
Osmolar Concentration
SOS Response, Genetics
Salmonella typhimurium
Ultraviolet Rays

Source

Open in PubMed

Identifiers

PMID: 1315267
DOI: 10.1002/em.2850190302

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1315267-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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