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Article

Mutations in topA interfere with the inducible expression of DNA damage response loci in Salmonella typhimurium.

Environmental and molecular mutagenesis - 1 Jan 1992

Smith C M, Arany Z, Orrego C, Eisenstadt E

Abstract excerpt

Strains of Salmonella typhimurium deficient in topoisomerase I activity (topA mutants) are UV sensitive and non-mutable (Overbye and Margolin: J Bacteriol 146:170-178, 1981). Using lac-operon fusions to DNA damage inducible (din) loci we investigated whether these observations could be explained by an inability of topA strains to efficiently induce DNA damage responses. Mitomycin C (MMC)-induced expression of...

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PMID: 1315267
DOI: 10.1002/em.2850190302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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