Article
Genetic influence on the structural variations of the abnormal prion protein.
Proceedings of the National Academy of Sciences of the United States of America - 29 Aug 2000
Parchi P, Zou W, Wang W, Brown P, Capellari S, Ghetti B, Kopp N, Schulz-Schaeffer W J, Kretzschmar H A, Head M W, Ironside J W, Gambetti P, Chen S G
Abstract excerpt
Prion diseases are characterized by the presence of the abnormal prion protein PrP(Sc), which is believed to be generated by the conversion of the alpha-helical structure that predominates in the normal PrP isoform into a beta-sheet structure resistant to proteinase K (PK). In human prion diseases, two major types of PrP(Sc), type 1 and 2, can be distinguished based on the difference in electrophoretic migration...
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