Cautionary insights on knockout mouse studies: the gene or not the gene?

doi:10.1016/j.bbi.2008.09.001

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Article

Cautionary insights on knockout mouse studies: the gene or not the gene?

Brain, behavior, and immunity - 1 Mar 2009

Eisener-Dorman Amy F, Lawrence David A, Bolivar Valerie J

Abstract excerpt

Gene modification technologies play a vital role in the study of biological systems and pathways. Although there is widespread and beneficial use of genetic mouse models, potential shortcomings of gene targeting technology exist, and are not always taken into consideration. Oversights associated with the technology can lead to misinterpretation of results; for example, ablation of a gene of interest can appear to...

Topics

Animals
Gene Targeting
Interleukin-10
Mice
Mice, Knockout
Mutation
Phenotype
Stem Cells

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Identifiers

PMID: 18822367
DOI: 10.1016/j.bbi.2008.09.001
PMCID: PMC2746382

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