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Article

Correction of the Bloom syndrome cellular phenotypes.

Somatic cell and molecular genetics - 1 Sept 1997

Giesler T, Baker K, Zhang B, McDaniel L D, Schultz R A

Abstract excerpt

Bloom syndrome (BLM) is a genetic disorder associated with predisposition to cancer and chromosome instability. However, the most readily recognized clinical feature of the syndrome is growth retardation. Introduction of the previously cloned BLM gene into BLM cells yielded correction of the chromosome instability and slow growth phenotypes. Additionally, asynchronous cultures of complemented clones revealed a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9546074
DOI: 10.1007/BF02674278

Genes

BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Clinical features of Bloom syndrome and function of the causative gene, BLM helicaseSemantic proximity Read ↗

Transfection of BLM into cultured bloom syndrome cells reduces the sister-chromatid exchange rate toward normal.Semantic proximity Read ↗

Genomic instability and cancer: lessons from analysis of Bloom's syndrome.Semantic proximity Read ↗

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