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Article

Hoxa1 and Krox-20 synergize to control the development of rhombomere 3.

Development (Cambridge, England) - 1 Dec 1998

Helmbacher F, Pujades C, Desmarquet C, Frain M, Rijli F M, Chambon P, Charnay P

Abstract excerpt

The transcription factor genes Hoxa1 and Krox-20 have been shown to play important roles in vertebrate hindbrain segmentation. In this report, we present evidence for novel functions of these genes which co-operate in specifying cellular identity in rhombomere (r) 3. Although Hoxa1 has not been observed to be expressed rostrally to the prospective r3/r4 boundary, its inactivation results in (i) the appearance of...

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Identifiers

PMID: 9806922
DOI: 10.1242/dev.125.23.4739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hoxa1 and Krox-20 synergize to control the development of rhombomere 3.PMID 9806922Read ↗

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Analysis of mouse kreisler mutants reveals new roles of hindbrain-derived signals in the establishment of the otic neurogenic domain.Semantic proximity Read ↗

Altered rhombomere-specific gene expression and hyoid bone differentiation in the mouse segmentation mutant, kreisler (kr).Semantic proximity Read ↗

Hoxb-2 transcriptional activation in rhombomeres 3 and 5 requires an evolutionarily conserved cis-acting element in addition to the Krox-20 binding site.Semantic proximity Read ↗

Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning.Semantic proximity Read ↗

Krox20 hindbrain regulation incorporates multiple modes of cooperation between cis-acting elements.Semantic proximity Read ↗

Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20.Semantic proximity Read ↗

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Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain.Semantic proximity Read ↗

Analysis of hindbrain patterning defects caused by the kreisler(enu) mutation reveals multiple roles of Kreisler in hindbrain segmentation.Semantic proximity Read ↗

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