Article
Hoxa1 and Krox-20 synergize to control the development of rhombomere 3.
Development (Cambridge, England) - 1 Dec 1998
Helmbacher F, Pujades C, Desmarquet C, Frain M, Rijli F M, Chambon P, Charnay P
Abstract excerpt
The transcription factor genes Hoxa1 and Krox-20 have been shown to play important roles in vertebrate hindbrain segmentation. In this report, we present evidence for novel functions of these genes which co-operate in specifying cellular identity in rhombomere (r) 3. Although Hoxa1 has not been o...
Topics
- Animals
- Axons
- Crosses, Genetic
- DNA-Binding Proteins
- Early Growth Response Protein 2
- Embryonic and Fetal Development
- Female
- Gene Dosage
- Genotype
- Heterozygote
- Homeodomain Proteins
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mice, Knockout
- Motor Neurons
- Neurons