Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain.

doi:10.1242/dev.118.4.1063

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Article

Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain.

Development (Cambridge, England) - 1 Aug 1993

Carpenter E M, Goddard J M, Chisaka O, Manley N R, Capecchi M R

Abstract excerpt

Targeted disruption of the murine hox-A1 gene results in severe defects in the formation of the hindbrain and associated cranial ganglia and nerves. Carbocyanine dye injections were used to trace afferent and efferent projections to and from the hindbrain in hox-A1-/hox-A1- mutant mice. Defects w...

Topics

Animals
Cell Movement
Gene Expression
Genes, Homeobox
Genotype
In Situ Hybridization
Mice
Mice, Mutant Strains
Morphogenesis
Motor Neurons
Neurons, Afferent
Neurons, Efferent
Rhombencephalon

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