Article
Analysis of mouse kreisler mutants reveals new roles of hindbrain-derived signals in the establishment of the otic neurogenic domain.
Developmental biology - 1 Oct 2008
Vázquez-Echeverría Citlali, Dominguez-Frutos Elena, Charnay Patrick, Schimmang Thomas, Pujades Cristina
Abstract excerpt
The inner ear, the sensory organ responsible for hearing and balance, contains specialized sensory and non-sensory epithelia arranged in a highly complex three-dimensional structure. To achieve this complexity, a tight coordination between morphogenesis and cell fate specification is essential during otic development. Tissues surrounding the otic primordium, and more particularly the adjacent segmented hindbrain,...
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