Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20.

doi:10.1101/gad.7.11.2071

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20.

Genes & development - 1 Nov 1993

Swiatek P J, Gridley T

Abstract excerpt

Krox20 is a zinc finger gene expressed in rhombomeres 3 and 5 during hindbrain development in vertebrates. Mice homozygous for a targeted mutation that deletes the majority of the Krox20 genes, including the zinc finger DNA-binding domain, died shortly after birth. The primary phenotype of the ho...

Topics

Amino Acid Sequence
Animals
Animals, Newborn
Base Sequence
Blastocyst
Blotting, Southern
DNA
DNA Primers
DNA-Binding Proteins
Early Growth Response Protein 2
Embryo, Mammalian
Female
Gene Deletion
Genes, Lethal
Genomic Library
Genotype
Glossopharyngeal Nerve
Homozygote

Source

Open in PubMed

Identifiers

PMID: 8224839
DOI: 10.1101/gad.7.11.2071

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8224839-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics