Differential retention of tumor- and differentiation-suppressor functions in cells derived from a human squamous cell carcinoma.

doi:10.1002/mc.2940050408

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Differential retention of tumor- and differentiation-suppressor functions in cells derived from a human squamous cell carcinoma.

Molecular carcinogenesis - 1 Jan 1992

Jaffe D R, Montero-Puerner Y, Beckett M A, Cowan J M, Weichselbaum R R, Diamond A M

Abstract excerpt

Three morphologically distinct cell lines--F.2a, V, and B.2--were isolated from a single human squamous cell carcinoma. Although all three cell lines can grow indefinitely in culture, they differ in a number of important transformation-related phenotypes. Only B.2 is strongly tumorigenic when injected into the flanks of nude mice, and only V can efficiently grow in semisolid media. The dominance of these traits...

Topics

Animals
Carcinoma, Squamous Cell
Cell Adhesion
Cell Differentiation
Cell Division
Cell Fusion
Cell Line
Culture Media, Serum-Free
Epidermal Growth Factor
Genetic Markers
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Keratinocytes

Mice

Mice, Nude

Neoplasm Transplantation

Phenotype

Transfection

Transforming Growth Factor alpha

Source

Open in PubMed

Identifiers

PMID: 1497804
DOI: 10.1002/mc.2940050408

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1497804-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential retention of tumor- and differentiation-suppressor functions in cells derived from a human squamous cell carcinoma.PMID 1497804Read ↗

Transforming growth factor beta 1 induces squamous carcinoma cell variants with increased metastatic abilities and a disorganized cytoskeleton.Semantic proximity Read ↗

Suppression of tumorigenicity of a human lung carcinoma line by nontumorigenic bronchial epithelial cells in somatic cell hybrids.Semantic proximity Read ↗

Metastatic variants derived following in vivo tumor progression of an in vitro transformed squamous cell carcinoma line acquire a differential growth advantage requiring tumor-host interaction.Semantic proximity Read ↗

Squamous cell carcinomas of the head and neck cultured in floating collagen gels: 1. The maintenance of stromal and epithelial elements in vitro without fibroblast overgrowth.Semantic proximity Read ↗

Characterization of mutant HA-ras gene expression in transformed murine keratinocyte lines grown under in vitro and in vivo conditions.Semantic proximity Read ↗

Suppression of the transformed phenotype in hybrids of human T-cell leukemia virus type I tax-transformed rat fibroblasts and normal human fibroblasts.Semantic proximity Read ↗

c-Ha-ras oncogene expression in immortalized human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy.Semantic proximity Read ↗

Sequential loss of suppressor genes for three specific functions during in vivo carcinogenesis.Semantic proximity Read ↗

JNK-associated scattered growth of YD-10B oral squamous carcinoma cells while maintaining the epithelial phenotype.Semantic proximity Read ↗

High‐throughput live‐cell imaging reveals differential inhibition of tumor cell proliferation by human fibroblastsSemantic proximity Read ↗

Changes of phenotypic characteristics of variants derived from Lewis lung carcinoma during long-term in vitro growth.Semantic proximity Read ↗

Altered response of a human squamous cell carcinoma cell line to 1, 25-dihydroxyvitamin D(3) after transfer of a normal chromosome 11.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.