Article
Murine squamous cell carcinoma cell lines produced by a complete carcinogenesis protocol with benzo[a]pyrene exhibit characteristic p53 mutations and the absence of H-ras and cyl 1/cyclin D1 abnormalities.
Carcinogenesis - 1 Aug 1994
Ruggeri B A, Bauer B, Zhang S Y, Klein-Szanto A J
Abstract excerpt
In this report, we describe the isolation and characterization of six murine squamous cell carcinoma cell lines (BPCC) derived from carcinomas produced by a complete carcinogenesis protocol with benzo[a]pyrene (B[a]P). All six cell lines were tumorigenic to varying degrees in nude mice, and sever...
Topics
- Animals
- Benzo(a)pyrene
- Carcinoma, Squamous Cell
- Cyclin D1
- Cyclins
- Genes, p53
- Genes, ras
- Mice
- Mice, Inbred BALB C
- Mutation
- Oncogene Proteins
- Rats
- Skin Neoplasms