Article
Impact of heterozygosity for the chemokine receptor CCR5 32-bp-deleted allele on plasma virus load and CD4 T lymphocytes in perinatally human immunodeficiency virus-infected children at 8 years of age.
The Journal of infectious diseases - 1 Oct 1998
Buseyne F, Janvier G, Teglas J P, Ivanoff S, Burgard M, Bui E, Mayaux M J, Blanche S, Rouzioux C, Rivière Y
Abstract excerpt
The CCR5 gene encodes one of the major human immunodeficiency virus type 1 (HIV-1) coreceptors. A 32-bp deletion in this gene (delta ccr5) is associated with relative resistance to disease progression in heterozygous HIV-1-infected persons. The effect of this mutation on virologic and immunologic...
Topics
- Acquired Immunodeficiency Syndrome
- CD4 Lymphocyte Count
- CD8-Positive T-Lymphocytes
- Child
- Follow-Up Studies
- HIV Antigens
- HIV Infections
- HIV-1
- Heterozygote
- Humans
- Infectious Disease Transmission, Vertical
- Mutation
- Receptors, CCR5