Article
Impact of heterozygosity for the chemokine receptor CCR5 32-bp-deleted allele on plasma virus load and CD4 T lymphocytes in perinatally human immunodeficiency virus-infected children at 8 years of age.
The Journal of infectious diseases - 1 Oct 1998
Buseyne F, Janvier G, Teglas J P, Ivanoff S, Burgard M, Bui E, Mayaux M J, Blanche S, Rouzioux C, Rivière Y
Abstract excerpt
The CCR5 gene encodes one of the major human immunodeficiency virus type 1 (HIV-1) coreceptors. A 32-bp deletion in this gene (delta ccr5) is associated with relative resistance to disease progression in heterozygous HIV-1-infected persons. The effect of this mutation on virologic and immunologic parameters was determined in a cohort of 45 perinatally HIV-1-infected children prospectively followed after 5 years...
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