Article
Biological functions of p53 isoforms through evolution: lessons from animal and cellular models.
Cell death and differentiation - 1 Dec 2011
Marcel V, Dichtel-Danjoy M-L, Sagne C, Hafsi H, Ma D, Ortiz-Cuaran S, Olivier M, Hall J, Mollereau B, Hainaut P, Bourdon J-C
Abstract excerpt
The TP53 tumour-suppressor gene is expressed as several protein isoforms generated by different mechanisms, including use of alternative promoters, splicing sites and translational initiation sites, that are conserved through evolution and within the TP53 homologues, TP63 and TP73. Although first described in the eighties, the importance of p53 isoforms in regulating the suppressive functions of p53 has only...
Topics
- Amino Acid Sequence
- Animals
- Disease Models, Animal
- Evolution, Molecular
- Humans
- Molecular Sequence Data
- Mutation
- Neoplasms
- Protein Isoforms
- Tumor Suppressor Protein p53