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Article

p53 Family: Role of Protein Isoforms in Human Cancer

1 Jan 2012

Abstract excerpt

TP53, TP63, and TP73 genes comprise the p53 family. Each gene produces protein isoforms through multiple mechanisms including extensive alternative mRNA splicing. Accumulating evidence shows that these isoforms play a critical role in the regulation of many biological processes in normal cells. Their abnormal expression contributes to tumorigenesis and has a profound effect on tumor response to curative therapy....

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Identifiers

PMID: 22007292
DOI: 10.1155/2012/687359

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