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p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies

9 Jun 2021

Abstract excerpt

The p53 tumor suppressor protein is crucial for cell growth control and the maintenance of genomic stability. Later discovered, p63 and p73 share structural and functional similarity with p53. To understand the p53 pathways more profoundly, all family members should be considered. Each family member possesses two promoters and alternative translation initiation sites, and they undergo alternative splicing,...

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PMID: 34207603
DOI: 10.3390/cancers13122885

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