Article
p53 Family isoforms.
Current pharmaceutical biotechnology - 1 Dec 2007
Bourdon Jean-Christophe
Abstract excerpt
p63, p73 and p53 are transcription factors members of the p53 gene family involved in development, differentiation and cell response to stress. p53 gene is mutated in 50% of human cancer. Moreover, when p53 gene is not mutated then its tumour suppressor pathway is lost through interaction with abnormally expressed cellular protein or viral protein. Therefore p53 pathway inactivation is a common denominator to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
