Persistent polyclonal B lymphocytosis: an expansion of cells showing IgVH gene mutations and phenotypic features of normal lymphocytes from the CD27+ marginal zone B-cell compartment.

Abstract excerpt

Persistent polyclonal B-cell lymphocytosis (PPBL) is an unusual and benign lymphoproliferation characterized by a polyclonal expansion of B lymphocytes, whose nature remains undetermined. The phenotypic analysis of three cases revealed that these cells were CD27+ IgM(high) CD21(high) CD5(low) and CD23(low), a phenotype associated with the normal marginal zone (MZ) B-cell compartment. As MZ B cells have initiated...

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