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Article

Two distinct cytoplasmic regions of the beta2 integrin chain regulate RhoA function during phagocytosis.

The Journal of cell biology - 27 Mar 2006

Wiedemann Agnès, Patel Jayesh C, Lim Jenson, Tsun Andy, van Kooyk Yvette, Caron Emmanuelle

Abstract excerpt

AlphaMbeta2 integrins mediate phagocytosis of opsonized particles in a process controlled by RhoA, Rho kinase, myosin II, Arp2/3, and actin polymerization. AlphaMbeta2, Rho, Arp2/3, and F-actin accumulate underneath bound particles; however, the mechanism regulating Rho function during alphaMbeta2-mediated phagocytosis is poorly understood. We report that the binding of C3bi-opsonized sheep red blood cells (RBCs)...

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Share to CD18 Antigens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16567504
DOI: 10.1083/jcb.200508075
PMCID: PMC2063764

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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