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Article

Ras-related GTPases Rap1 and RhoA collectively induce the phagocytosis of serum-opsonized zymosan particles in macrophages.

The Journal of biological chemistry - 10 Feb 2012

Kim Jae-Gyu, Moon Mi-Young, Kim Hee-Jun, Li Yi, Song Dong-Keun, Kim Jun-Sub, Lee Jae-Yong, Kim Jaebong, Kim Sung-Chan, Park Jae-Bong

Abstract excerpt

Phagocytosis occurs primarily through two main processes in macrophages: the Fcγ receptor- and the integrin αMβ2-mediated processes. Complement C3bi-opsonized particles are known to be engulfed through integrin αMβ2-mediated process, which is regulated by RhoA GTPase. C3 toxin fused with Tat-peptide (Tat-C3 toxin), an inhibitor of the Rho GTPases, was shown to markedly inhibit the phagocytosis of serum...

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Identifiers

PMID: 22194606
DOI: 10.1074/jbc.M111.257634
PMCID: PMC3281652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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