Article
alpha-latrotoxin action probed with recombinant toxin: receptors recruit alpha-latrotoxin but do not transduce an exocytotic signal.
The EMBO journal - 2 Nov 1998
Ichtchenko K, Khvotchev M, Kiyatkin N, Simpson L, Sugita S, Südhof T C
Abstract excerpt
alpha-Latrotoxin stimulates neurotransmitter release probably by binding to two receptors, CIRL/latrophilin 1 (CL1) and neurexin Ialpha. We have now produced recombinant alpha-latrotoxin (LtxWT) that is as active as native alpha-latrotoxin in triggering synaptic release of glutamate, GABA and nor...
Topics
- Animals
- Cadmium
- Cysteine
- Exocytosis
- Glycoproteins
- Lanthanum
- Mice
- Mutation
- Nerve Tissue Proteins
- Neuropeptides
- Neurotransmitter Agents
- Phosphatidylinositols
- Protein Binding
- Receptors, Peptide
- Recombinant Proteins
- Signal Transduction
- Spider Venoms
- Synaptosomes