Article
alpha-Latrotoxin, acting via two Ca2+-dependent pathways, triggers exocytosis of two pools of synaptic vesicles.
The Journal of biological chemistry - 30 Nov 2001
Ashton A C, Volynski K E, Lelianova V G, Orlova E V, Van Renterghem C, Canepari M, Seagar M, Ushkaryov Y A
Abstract excerpt
alpha-Latrotoxin stimulates three types of [(3)H]gamma-aminobutyric acid and [(14)C]glutamate release from synaptosomes. The Ca(2+)-independent component (i) is insensitive to SNAP-25 cleavage or depletion of vesicle contents by bafilomycin A1 and represents transmitter efflux mediated by alpha-latrotoxin pores. Two other components of release are Ca(2+)-dependent and vesicular but rely on distinct mechanisms....
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