Article
Latrophilin, neurexin, and their signaling-deficient mutants facilitate alpha -latrotoxin insertion into membranes but are not involved in pore formation.
The Journal of biological chemistry - 29 Dec 2000
Volynski K E, Meunier F A, Lelianova V G, Dudina E E, Volkova T M, Rahman M A, Manser C, Grishin E V, Dolly J O, Ashley R H, Ushkaryov Y A
Abstract excerpt
Pure alpha-latrotoxin is very inefficient at forming channels/pores in artificial lipid bilayers or in the plasma membrane of non-secretory cells. However, the toxin induces pores efficiently in COS-7 cells transfected with the heptahelical receptor latrophilin or the monotopic receptor neurexin. Signaling-deficient (truncated) mutants of latrophilin and latrophilin-neurexin hybrids also facilitate pore...
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