Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of alpha-latrotoxin receptors in neuromuscular synapses leads to a prolonged splash acetylcholine release.

Bulletin of experimental biology and medicine - 1 Jun 2009

Lelyanova V G, Thomson D, Ribchester R R, Tonevitsky E A, Ushkaryov Y A

Abstract excerpt

The mechanisms of acetylcholine release in presynaptic terminals of motoneurons induced by mutant alpha-latrotoxin (LT(N4C)) were analyzed. In contrast to wild-type alpha-latrotoxin that causes both continuous and splash secretion of acetylcholine and necessarity block neuromuscular transmission,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcholine
Share to Electrophysiology
Share to Exocytosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Receptors, Peptide

Share to Synapses

Source

Identifiers

PMID: 19902061
DOI: 10.1007/s10517-009-0600-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19902061-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of alpha-latrotoxin receptors in neuromuscular synapses leads to a prolonged splash acetylcholine release.PMID 19902061Read ↗

alpha-Latrotoxin, acting via two Ca2+-dependent pathways, triggers exocytosis of two pools of synaptic vesicles.Semantic proximity Read ↗

alpha-latrotoxin action probed with recombinant toxin: receptors recruit alpha-latrotoxin but do not transduce an exocytotic signal.Semantic proximity Read ↗

Mutant alpha-latrotoxin (LTXN4C) does not form pores and causes secretion by receptor stimulation: this action does not require neurexins.Semantic proximity Read ↗

Compensatory contribution of Cav2.3 channels to acetylcholine release at the neuromuscular junction of tottering mice.Semantic proximity Read ↗

End-plate acetylcholine receptor: structure, mechanism, pharmacology, and disease.Semantic proximity Read ↗

Botulinum Neurotoxins in Central Nervous System: An Overview from Animal Models to Human TherapySemantic proximity Read ↗

Chronic acetylcholinesterase overexpression induces multilevelled aberrations in mouse neuromuscular physiology.Semantic proximity Read ↗

Microscopic kinetics and structure-function analysis in the vesicular acetylcholine transporter.Semantic proximity Read ↗

Desensitization contributes to the synaptic response of gain-of-function mutants of the muscle nicotinic receptor.Semantic proximity Read ↗

Neuronal nicotinic threonine-for-leucine 247 alpha7 mutant receptors show different gating kinetics when activated by acetylcholine or by the noncompetitive agonist 5-hydroxytryptamine.Semantic proximity Read ↗

Latrophilin, neurexin, and their signaling-deficient mutants facilitate alpha -latrotoxin insertion into membranes but are not involved in pore formation.Semantic proximity Read ↗

Alpha-latrotoxin modulates the secretory machinery via receptor-mediated activation of protein kinase C.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.