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Article

Cre-mediated recombination can induce apoptosis in vivo by activating the p53 DNA damage-induced pathway.

Genesis (New York, N.Y. : 2000) - 1 Feb 2012

Zhu Jianjian, Nguyen Minh-Thanh, Nakamura Eiichiro, Yang Junming, Mackem Susan

Abstract excerpt

Cre-mediated apoptosis has been observed in many contexts in mice expressing Cre-recombinase and can confound the analysis of genetically engineered conditional mutant or transgenic alleles. Several mechanisms have been proposed to explain this phenomenon. We find that the degree of apoptosis induced correlates roughly with the copy number of loxP sites present in the genome and that some level of increased...

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Identifiers

PMID: 21913308
DOI: 10.1002/dvg.20799
PMCID: PMC3273649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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