Article
Relationship between IkappaBalpha constitutive expression, TNFalpha synthesis, and apoptosis in EBV-infected lymphoblastoid cells.
Oncogene - 24 Sept 1998
Asso-Bonnet M, Feuillard J, Ferreira V, Bissières P, Tarantino N, Körner M, Raphael M
Abstract excerpt
In order to understand the role of NF-kappaB in EBV transformation we have established stably transfected IkappaBalpha into lymphoblastoid cells. Two clones were obtained in which the loss of NF-kappaB binding activity correlated with the constitutive expression of the transgenic IkappaBalpha. Pr...
Topics
- Apoptosis
- B-Lymphocytes
- Cell Division
- Cell Transformation, Neoplastic
- Cell Transformation, Viral
- Cytokines
- DNA, Complementary
- DNA-Binding Proteins
- Herpesvirus 4, Human
- Humans
- I-kappa B Proteins
- NF-KappaB Inhibitor alpha
- NF-kappa B
- Phenotype
- Transfection
- Tumor Necrosis Factor-alpha