Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NF-kappaB overrides the apoptotic program of TNF receptor 1 but not CD40 in carcinoma cells.

Cellular signalling - 1 Jun 2005

Davies Clare C, Bem Danai, Young Lawrence S, Eliopoulos Aristides G

Abstract excerpt

The activation of NF-kappaB and phosphatidylinositol-3 (PI3) kinase by TNF-alpha and TRAIL overrides the pro-apoptotic effects of these ligands in carcinoma cells and hinders their therapeutic application. In this report we show that CD40 ligand, another member of the TNF superfamily, also triggers the activation of these signalling pathways but, importantly, utilises only the PI3 kinase cascade for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD40 Antigens
Share to CD40 Ligand
Share to I-kappa B Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NF-kappa B

Share to NF-KappaB Inhibitor alpha

Share to Phosphoinositide-3 Kinase Inhibitors

Share to Proto-Oncogene Proteins c-akt

Share to Receptors, Tumor Necrosis Factor, Type I

Source

Identifiers

PMID: 15722197
DOI: 10.1016/j.cellsig.2004.10.014

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NF-kappaB overrides the apoptotic program of TNF receptor 1 but not CD40 in carcinoma cells.PMID 15722197Read ↗

TNF inhibited the apoptosis by activation of Akt serine/threonine kinase in the human head and neck squamous cell carcinoma.Semantic proximity Read ↗

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling.Semantic proximity Read ↗

Negative control of TRAIL-R1 signaling by transforming growth factor β1 in pancreatic tumor cells involves Smad-dependent down regulation of TRAIL-R1.Semantic proximity Read ↗

Stat3 and NF-kappaB activation prevents apoptosis in pancreatic carcinogenesis.Semantic proximity Read ↗

NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling.Semantic proximity Read ↗

Primary and Malignant Cholangiocytes Undergo CD40 Mediated Fas Dependent Apoptosis, but Are Insensitive to Direct Activation with Exogenous Fas LigandSemantic proximity Read ↗

Unraveling the intracellular cross-talk governing the balance between TNF <i>α</i> mediated survival and apoptosis signalingSemantic proximity Read ↗

Inhibition of NF-kappaB sensitizes A431 cells to epidermal growth factor-induced apoptosis, whereas its activation by ectopic expression of RelA confers resistance.Semantic proximity Read ↗

Induction of cell death by stimulation of protein kinase C in human epithelial cells expressing a mutant ras oncogene: a potential therapeutic target.Semantic proximity Read ↗

Simultaneous inhibition of Rac1 and IKK pathways sensitizes lung cancer cells to TNFalpha-mediated apoptosis.Semantic proximity Read ↗

NF-kappaB activation but not PI3K/Akt is required for dexamethasone dependent protection against TNF-alpha cytotoxicity in L929 cells.Semantic proximity Read ↗

PI3K inhibition potentiates Bcl‐2‐dependent apoptosis in renal carcinoma cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.