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Article

Role of IRS and PHIP on insulin-induced tyrosine phosphorylation and distribution of IRS proteins.

Cell structure and function - 1 Jan 2007

Kaburagi Yasushi, Okochi Hitoshi, Satoh Shinobu, Yamashita Ryo, Hamada Keiko, Ikari Kohei, Yamamoto-Honda Ritsuko, Terauchi Yasuo, Yasuda Kazuki, Noda Mitsuhiko

Abstract excerpt

To analyze the functional differences of the insulin receptor substrate (IRS) family, the N-terminal fragments containing the pleckstrin homology (PH) domains and the phosphotyrosine-binding (PTB) domains of IRS (IRS-N) proteins, as well as intact IRS molecules, were expressed in Cos-1 cells, and insulin-induced tyrosine phosphorylation and subcellular distribution of IRS proteins were analyzed. In contrast to...

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Identifiers

PMID: 17634669
DOI: 10.1247/csf.07003

Genes

PHIP
IRS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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