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Article

Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation.

Molecular and cellular biology - 1 Aug 2000

Filippa N, Sable C L, Hemmings B A, Van Obberghen E

Abstract excerpt

In this report we investigated the function of phosphoinositide-dependent protein kinase 1 (PDK1) in protein kinase B (PKB) activation and translocation to the cell surface. Wild-type and PDK1 mutants were transfected into HeLa cells, and their subcellular localization was analyzed. PDK1 was found to translocate to the plasma membrane in response to insulin, and this process did not require a functional catalytic...

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Identifiers

PMID: 10891507
DOI: 10.1128/MCB.20.15.5712-5721.2000
PMCID: PMC86048

Genes

PDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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