Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation.

doi:10.1128/MCB.20.15.5712-5721.2000

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Article

Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation.

Molecular and cellular biology - 1 Aug 2000

Filippa N, Sable C L, Hemmings B A, Van Obberghen E

Abstract excerpt

In this report we investigated the function of phosphoinositide-dependent protein kinase 1 (PDK1) in protein kinase B (PKB) activation and translocation to the cell surface. Wild-type and PDK1 mutants were transfected into HeLa cells, and their subcellular localization was analyzed. PDK1 was found to translocate to the plasma membrane in response to insulin, and this process did not require a functional catalytic...

Topics

3-Phosphoinositide-Dependent Protein Kinases
Biological Transport
Cell Line
Cell Membrane
Enzyme Activation
Humans
Insulin
Insulin Receptor Substrate Proteins
Microscopy, Confocal
Mutation
Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphoproteins

Protein Serine-Threonine Kinases

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-akt

Recombinant Proteins

Subcellular Fractions

Source

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Identifiers

PMID: 10891507
DOI: 10.1128/MCB.20.15.5712-5721.2000
PMCID: PMC86048

Genes

PDK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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