Article
Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB.
The Journal of biological chemistry - 22 May 1998
van Weeren P C, de Bruyn K M, de Vries-Smits A M, van Lint J, Burgering B M
Abstract excerpt
Activation of phosphatidylinositide 3'-OH kinase (PI 3-kinase) is implicated in mediating a variety of growth factor-induced responses, among which are the inactivation of glycogen synthase kinase-3 (GSK-3) and the activation of the serine/threonine protein kinase B (PKB). GSK-3 inactivation occu...
Topics
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Line
- Cell Membrane
- Cytosol
- Enzyme Activation
- Glycogen Synthase Kinase 3
- Glycogen Synthase Kinases
- Insulin
- Mutation
- Oncogene Protein p21(ras)
- Phosphatidylinositol 3-Kinases