Article
Maximal transcriptional activation by the IHF protein of Escherichia coli depends on optimal DNA bending by the activator.
Molecular microbiology - 1 Oct 1998
Engelhorn M, Geiselmann J
Abstract excerpt
Transcriptional activation in prokaryotes can be mediated by at least two different mechanisms: direct contacts between the activator and RNA polymerase or modulation of the overall geometry of DNA. In the latter case, an activator protein that bends DNA favours contacts between the DNA upstream...
Topics
- Bacterial Proteins
- Base Sequence
- Binding Sites
- DNA, Bacterial
- DNA-Binding Proteins
- DNA-Directed RNA Polymerases
- Escherichia coli
- Escherichia coli Proteins
- Genes, Reporter
- Integration Host Factors
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Protein Conformation
- Transcription Factors
- Transcriptional Activation