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Article

Promoter protection by a transcription factor acting as a local topological homeostat.

EMBO reports - 1 Apr 2002

Rochman Mark, Aviv Michal, Glaser Gad, Muskhelishvili Georgi

Abstract excerpt

Binding of the Escherichia coli global transcription factor FIS to the upstream activating sequence (UAS) of stable RNA promoters activates transcription on the outgrowth of cells from stationary phase. Paradoxically, while these promoters require negative supercoiling of DNA for optimal activity, FIS counteracts the increase of negative superhelical density by DNA gyrase. We demonstrate that binding of FIS at...

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Identifiers

PMID: 11897661
DOI: 10.1093/embo-reports/kvf067
PMCID: PMC1084055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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