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Article

Genetic and biochemical analysis of the integration host factor of Escherichia coli.

Journal of molecular biology - 5 Jun 1993

Mengeritsky G, Goldenberg D, Mendelson I, Giladi H, Oppenheim A B

Abstract excerpt

Integration host factor (IHF) is a small, heterodimeric DNA-binding protein of Escherichia coli composed of two subunits, alpha and beta, encoded by the himA and hip genes, respectively. IHF binds to the minor groove at a consensus sequence and bends DNA. We mutagenized the hip gene and studied the activity of the mutant IHF proteins in vivo and in vitro. Substitutions at the C-terminal alpha-helix (alpha-helix...

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Source

Identifiers

PMID: 8515442
DOI: 10.1006/jmbi.1993.1316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic and biochemical analysis of the integration host factor of Escherichia coli.PMID 8515442Read ↗

The isolation and characterization of mutants of the integration host factor (IHF) of Escherichia coli with altered, expanded DNA-binding specificities.Semantic proximity Read ↗

Participation of the flank regions of the integration host factor protein in the specificity and stability of DNA binding.Semantic proximity Read ↗

Requirement of integration host factor (IHF) for growth of Escherichia coli deficient in HU protein.Semantic proximity Read ↗

Maximal transcriptional activation by the IHF protein of Escherichia coli depends on optimal DNA bending by the activator.Semantic proximity Read ↗

Mutants of Escherichia coli integration host factor: DNA-binding and recombination properties.Semantic proximity Read ↗

Participation of the histone-like protein HU and of IHF in minichromosomal maintenance in Escherichia coli.Semantic proximity Read ↗

HU and IHF: similarities and differences. In Escherichia coli, the lack of HU is not compensated for by IHF.Semantic proximity Read ↗

The requirement of IHF protein for extrachromosomal replication of the Escherichia coli oriC in a mutant deficient in DNA polymerase I activity.Semantic proximity Read ↗

Molecular Dissection of Mycobacterium tuberculosis Integration Host Factor Reveals Novel Insights into the Mode of DNA Binding and Nucleoid Compaction.Semantic proximity Read ↗

Integration host factor is a negative effector of in vivo and in vitro expression of ompC in Escherichia coli.Semantic proximity Read ↗

Alterations in the p'R promoter of coliphage lambda modify both its activity and interaction with the integration host factor (IHF).Semantic proximity Read ↗

Transcriptional activation by protein-induced DNA bending: evidence for a DNA structural transmission model.Semantic proximity Read ↗

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