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Article

Genetic and biochemical analysis of the integration host factor of Escherichia coli.

Journal of molecular biology - 5 Jun 1993

Mengeritsky G, Goldenberg D, Mendelson I, Giladi H, Oppenheim A B

Abstract excerpt

Integration host factor (IHF) is a small, heterodimeric DNA-binding protein of Escherichia coli composed of two subunits, alpha and beta, encoded by the himA and hip genes, respectively. IHF binds to the minor groove at a consensus sequence and bends DNA. We mutagenized the hip gene and studied t...

Topics

Bacterial Proteins
Base Sequence
DNA, Bacterial
DNA-Binding Proteins
Deoxyribonuclease I
Electrophoresis, Polyacrylamide Gel
Escherichia coli
Genes, Bacterial
Integration Host Factors
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleic Acid Conformation

Protein Binding

Source

Identifiers

PMID: 8515442
DOI: 10.1006/jmbi.1993.1316

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8515442-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Genetic and biochemical analysis of the integration host factor of Escherichia coli.PMID 8515442Read ↗

The isolation and characterization of mutants of the integration host factor (IHF) of Escherichia coli with altered, expanded DNA-binding specificities.Semantic proximity Read ↗

Participation of the flank regions of the integration host factor protein in the specificity and stability of DNA binding.Semantic proximity Read ↗

Requirement of integration host factor (IHF) for growth of Escherichia coli deficient in HU protein.Semantic proximity Read ↗

Maximal transcriptional activation by the IHF protein of Escherichia coli depends on optimal DNA bending by the activator.Semantic proximity Read ↗

Mutants of Escherichia coli integration host factor: DNA-binding and recombination properties.Semantic proximity Read ↗

Participation of the histone-like protein HU and of IHF in minichromosomal maintenance in Escherichia coli.Semantic proximity Read ↗

HU and IHF: similarities and differences. In Escherichia coli, the lack of HU is not compensated for by IHF.Semantic proximity Read ↗

The requirement of IHF protein for extrachromosomal replication of the Escherichia coli oriC in a mutant deficient in DNA polymerase I activity.Semantic proximity Read ↗

Molecular Dissection of Mycobacterium tuberculosis Integration Host Factor Reveals Novel Insights into the Mode of DNA Binding and Nucleoid Compaction.Semantic proximity Read ↗

Integration host factor is a negative effector of in vivo and in vitro expression of ompC in Escherichia coli.Semantic proximity Read ↗

Alterations in the p'R promoter of coliphage lambda modify both its activity and interaction with the integration host factor (IHF).Semantic proximity Read ↗

Transcriptional activation by protein-induced DNA bending: evidence for a DNA structural transmission model.Semantic proximity Read ↗

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