Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transmembrane topology and oligomeric structure of the high-affinity choline transporter.

The Journal of biological chemistry - 14 Dec 2012

Okuda Takashi, Osawa Chieko, Yamada Haruhiko, Hayashi Kengo, Nishikawa Shizue, Ushio Tomoko, Kubo Yuji, Satou Motoyasu, Ogawa Haruo, Haga Tatsuya

Abstract excerpt

The high-affinity choline transporter CHT1 mediates choline uptake essential for acetylcholine synthesis in cholinergic nerve terminals. CHT1 belongs to the Na(+)/glucose cotransporter family (SLC5), which is postulated to have a common 13-transmembrane domain core; however, no direct experimental evidence for CHT1 transmembrane topology has yet been reported. We examined the transmembrane topology of human CHT1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Choline
Share to Cysteine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Dominant

Share to HEK293 Cells

Share to Mutant Proteins

Share to Protein Structure, Quaternary

Share to Structural Homology, Protein

Share to Symporters

Source

Open in PubMed Open full text

Identifiers

PMID: 23132865
DOI: 10.1074/jbc.M112.405027
PMCID: PMC3522279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transmembrane topology and oligomeric structure of the high-affinity choline transporter.PMID 23132865Read ↗

Structural insights into a conserved mechanism of choline translocation through CHTSemantic proximity Read ↗

Biochemical characterization of two novel mutations in the human high-affinity choline transporter 1 identified in a patient with congenital myasthenic syndrome.Semantic proximity Read ↗

Single nucleotide polymorphism of the human high affinity choline transporter alters transport rate.Semantic proximity Read ↗

The novel roles of choline transporter-like 1 and 2 in ethanolamine transportSemantic proximity Read ↗

SLC25A48 is a human mitochondrial choline transporterSemantic proximity Read ↗

Transmembrane topology of a CLC chloride channel.Semantic proximity Read ↗

Functional Distinction between Human and Mouse Sodium-Coupled Citrate Transporters and Its Biologic Significance: An Attempt for Structural Basis Using a Homology Modeling ApproachSemantic proximity Read ↗

Defective presynaptic choline transport underlies hereditary motor neuropathy.Semantic proximity Read ↗

CHDH, a key mitochondrial enzyme, plays a diagnostic role in metabolic disorders diseases and tumor progressionSemantic proximity Read ↗

FRET-Assisted Determination of CLN3 Membrane TopologySemantic proximity Read ↗

The cysteines of the extracellular loop are crucial for trafficking of human organic cation transporter 2 to the plasma membrane and are involved in oligomerization.Semantic proximity Read ↗

Choline transporter mutations in severe congenital myasthenic syndrome disrupt transporter localizationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.