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Article

TGFBR2 and BAX mononucleotide tract mutations, microsatellite instability, and prognosis in 1072 colorectal cancers.

PloS one - 1 Jan 2011

Shima Kaori, Morikawa Teppei, Yamauchi Mai, Kuchiba Aya, Imamura Yu, Liao Xiaoyun, Meyerhardt Jeffrey A, Fuchs Charles S, Ogino Shuji

Abstract excerpt

BACKGROUND: Mononucleotide tracts in the coding regions of the TGFBR2 and BAX genes are commonly mutated in microsatellite instability-high (MSI-high) colon cancers. The receptor TGFBR2 plays an important role in the TGFB1 (transforming growth factor-β, TGF-β) signaling pathway, and BAX plays a key role in apoptosis. However, a role of TGFBR2 or BAX mononucleotide mutation in colorectal cancer as a prognostic...

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Source

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Identifiers

PMID: 21949851
DOI: 10.1371/journal.pone.0025062
PMCID: PMC3176811

Genes

TGFBR2
BAX
BRAF
KRAS
TGFB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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