Article
Genetic alterations of sporadic colorectal cancer with microsatellite instability, especially characteristics of primary multiple colorectal cancers.
Journal of surgical oncology - 1 Aug 2000
Abe Y, Masuda H
Abstract excerpt
BACKGROUND AND OBJECTIVES: The purpose of this study was to elucidate genetic alterations of sporadic colorectal cancers with Microsatellite instability (MSI). METHODS: One hundred and ten patients with sporadic colorectal cancer were examined. The MSI was assessed using eight microsatellite markers. In addition, mutation analysis was performed for Transforming growth-beta type II receptor (TGF beta R II), bcl-2...
Topics
- Base Sequence
- Colorectal Neoplasms
- DNA Mutational Analysis
- DNA, Neoplasm
- Female
- Genetic Markers
- Humans
- Male
- Microsatellite Repeats
- Molecular Sequence Data
- Mutation
- Neoplasms, Multiple Primary
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Sensitivity and Specificity