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Article

Absence of PTEN germ-line mutations in men with a potential inherited predisposition to prostate cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 1999

Cooney K A, Tsou H C, Petty E M, Miesfeldt S, Ping X L, Gruener A C, Peacocke M

Abstract excerpt

Epidemiological studies have demonstrated that men with a family history of prostate cancer are at an increased risk for this disease. This important observation has led a number of research teams, including our own, to collect DNA samples and clinical data from prostate cancer families, with the goal of localizing and characterizing prostate cancer susceptibility genes. The candidate tumor suppressor gene PTEN...

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Source

Identifiers

PMID: 10389923

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Absence of PTEN germ-line mutations in men with a potential inherited predisposition to prostate cancer.PMID 10389923Read ↗

Germ-line sequence variants of PTEN do not have an important role in hereditary and non-hereditary prostate cancer susceptibility.Semantic proximity Read ↗

Unexpected cancer-predisposition gene variants in Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome patients without underlying germline PTEN mutations.Semantic proximity Read ↗

PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate.Semantic proximity Read ↗

Polymorphisms in PTEN in breast cancer families.Semantic proximity Read ↗

Lifetime Cancer Risks in Individuals with Germline<i>PTEN</i>MutationsSemantic proximity Read ↗

Germline mutations in the breast cancer susceptibility gene PTEN are rare in high-risk non-BRCA1/2 French Canadian breast cancer families.Semantic proximity Read ↗

Breast cancer risk and clinical implications for germline PTEN mutation carriers.Semantic proximity Read ↗

PTEN hamartoma tumour syndrome: what happens when there is no PTEN germline mutation?Semantic proximity Read ↗

Common genetic variation at PTEN and risk of sporadic breast and prostate cancer.Semantic proximity Read ↗

Haploinsufficiency of the <i>Pten</i> tumor suppressor gene promotes prostate cancer progressionSemantic proximity Read ↗

Evaluation of germline PTEN mutations in endometrial cancer patients.Semantic proximity Read ↗

Genetics of Cowden syndrome: through the looking glass of oncology.Semantic proximity Read ↗

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