Article
Concomitant expression of E. coli cytosine deaminase and uracil phosphoribosyltransferase improves the cytotoxicity of 5-fluorocytosine.
FEMS microbiology letters - 1 Oct 1998
Tiraby M, Cazaux C, Baron M, Drocourt D, Reynes J P, Tiraby G
Abstract excerpt
The prodrug activation system formed by the E. coli codA gene encoding cytosine deaminase (CD) and 5-fluorocytosine (5-FC) developed for selective cancer chemotherapy suffers from a sensitivity limitation in many tumour cells. In an attempt to improve the CD/5-FC suicide association, we combined...
Topics
- Animals
- Antimetabolites, Antineoplastic
- Artificial Gene Fusion
- Cytosine Deaminase
- Drug Resistance
- Escherichia coli
- Escherichia coli Proteins
- Flucytosine
- Fluorouracil
- Gene Expression
- Genes, Bacterial