Article
Concomitant expression of E. coli cytosine deaminase and uracil phosphoribosyltransferase improves the cytotoxicity of 5-fluorocytosine.
FEMS microbiology letters - 1 Oct 1998
Tiraby M, Cazaux C, Baron M, Drocourt D, Reynes J P, Tiraby G
Abstract excerpt
The prodrug activation system formed by the E. coli codA gene encoding cytosine deaminase (CD) and 5-fluorocytosine (5-FC) developed for selective cancer chemotherapy suffers from a sensitivity limitation in many tumour cells. In an attempt to improve the CD/5-FC suicide association, we combined the E. coli upp gene encoding uracil phosphoribosyltransferase (UPRT) with codA gene to create the situation prevailing...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.