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Inhibition of tumor growth by polyarginine-fused mutant cytosine deaminase.

Applied biochemistry and biotechnology - 1 Feb 2015

Wang Wenfei, Zhang Nan, Zhao Tingting, Liu Mingyao, Zhang Tong, Li Deshan

Abstract excerpt

Gene-directed enzyme-prodrug therapy is a method whereby cancerous tumors are selectively eradicated with minimal impact to healthy tissue. Due to its thermostability, E. coli cytosine deaminase (bCD) is one of the most widely used enzyme-prodrug combinations. However, wild-type bCD (wtbCD) displays a relatively poor turnover of 5-fluorocytosine (5-FC), and also has low permeability as a hexamer macromolecule (∼...

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PMID: 25416477
DOI: 10.1007/s12010-014-1389-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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