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Article

Redesigned Escherichia coli cytosine deaminase: a new facet of suicide gene therapy.

The journal of gene medicine - 1 Jan 2000

Raza Asif, Kohila V, Ghosh Siddhartha Sankar

Abstract excerpt

BACKGROUND: The Escherichia coli cytosine deaminase (CD)/5-fluorocytosine (5-FC) approach emerges as a potential aid for suicide gene therapy in the field of modern cancer treatment. However, the poor binding affinity of CD towards 5-FC compared to the natural substrate cytosine limits its application for successful suicide gene therapy. Redesigning a bacterial mutant CD with site-directed mutagenesis showed...

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PMID: 25982931
DOI: 10.1002/jgm.2831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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