Article
Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.
Chemistry & biology - 1 Dec 2003
Bennett Eric M, Anand Ruchi, Allan Paula W, Hassan Abdalla E A, Hong Jeong S, Levasseur Dana N, McPherson David T, Parker William B, Secrist John A, Sorscher Eric J, Townes Tim M, Waud William R, Ealick Steven E
Abstract excerpt
Activation of prodrugs by Escherichia coli purine nucleoside phosphorylase (PNP) provides a method for selectively killing tumor cells expressing a transfected PNP gene. This gene therapy approach requires matching a prodrug and a known enzymatic activity present only in tumor cells. The specificity of the method relies on avoiding prodrug cleavage by enzymes already present in the host cells or the intestinal...
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