Article
Strong enhancement of recombinant cytosine deaminase activity in Bifidobacterium longum for tumor-targeting enzyme/prodrug therapy.
Bioscience, biotechnology, and biochemistry - 1 Apr 2007
Hamaji Yoshinori, Fujimori Minoru, Sasaki Takayuki, Matsuhashi Hitomi, Matsui-Seki Keiichi, Shimatani-Shibata Yuko, Kano Yasunobu, Amano Jun, Taniguchi Shun'ichiro
Abstract excerpt
In our previous studies, a strain of the nonpathogenic, anaerobic, intestinal bacterium, Bifidobacterium longum (B. longum), was found to be localized selectively and to proliferate within solid tumors after systemic administration. In addition, B. longum transformed with the shuttle-plasmid encoding the cytosine deaminase (CD) gene expressed active CD, which deaminated the prodrug 5-fluorocytosine (5-FC) to the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.