Article
Mutation of Escherichia coli cytosine deaminase significantly enhances molecular chemotherapy of human glioma.
Gene therapy - 1 Jul 2007
Kaliberov S A, Market J M, Gillespie G Y, Krendelchtchikova V, Della Manna D, Sellers J C, Kaliberova L N, Black M E, Buchsbaum D J
Abstract excerpt
Combined treatment using adenoviral (Ad)-directed enzyme/prodrug therapy and radiation therapy has the potential to become a powerful method of cancer therapy. We have developed an Ad vector encoding a mutant bacterial cytosine deaminase (bCD) gene (AdbCD-D314A), which has a higher affinity for cytosine than wild-type bCD (bCDwt). The purpose of this study was to evaluate cytotoxicity in vitro and therapeutic...
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