Article
Novel selection for isoniazid (INH) resistance genes supports a role for NAD+-binding proteins in mycobacterial INH resistance.
Infection and immunity - 1 Nov 1998
Chen P, Bishai W R
Abstract excerpt
The genetic basis of isoniazid (INH) resistance remains unknown for a significant proportion of clinical isolates. To identify genes which might confer resistance by detoxifying or sequestering INH, we transformed the Escherichia coli oxyR mutant, which is relatively sensitive to INH, with a Myco...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Carrier Proteins
- Clone Cells
- DNA-Binding Proteins
- Drug Resistance, Microbial
- Escherichia coli
- Escherichia coli Proteins
- Genes, Bacterial
- Genetic Complementation Test
- Intramolecular Transferases
- Isoniazid
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Mycobacterium tuberculosis
- Receptor, trkA
- Repressor Proteins