Article
Mycobacterium tuberculosis dihydrofolate reductase is not a target relevant to the antitubercular activity of isoniazid.
Antimicrobial agents and chemotherapy - 1 Sept 2010
Wang Feng, Jain Paras, Gulten Gulcin, Liu Zhen, Feng Yicheng, Ganesula Krishna, Motiwala Alifiya S, Ioerger Thomas R, Alland David, Vilchèze Catherine, Jacobs William R, Sacchettini James C
Abstract excerpt
Mycobacterium tuberculosis enoyl-acyl-ACP reductase (InhA) has been demonstrated to be the primary target of isoniazid (INH). Recently, it was postulated that M. tuberculosis dihydrofolate reductase (DHFR) is also a target of INH, based on the findings that a 4R-INH-NADP adduct synthesized from INH by a nonenzymatic approach showed strong inhibition of DHFR in vitro, and overexpression of M. tuberculosis dfrA in...
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