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Article

Enhanced fMLP-stimulated chemotaxis in human neutrophils from individuals carrying the G protein beta3 subunit 825 T-allele.

FEBS letters - 2 Oct 1998

Virchow S, Ansorge N, Rübben H, Siffert G, Siffert W

Abstract excerpt

We have recently described a C825T polymorphism in the gene encoding for the Gbeta3 subunit of heterotrimeric G proteins. The 825T allele is associated with a novel splice variant (Gbeta3-s) and enhanced signal transduction via pertussis toxin (PTX)-sensitive G proteins. fMLP-induced chemotaxis,...

Topics

Alleles
Calcium
Chemotaxis, Leukocyte
GTP-Binding Proteins
Genotype
Humans
In Vitro Techniques
Kinetics
N-Formylmethionine Leucyl-Phenylalanine
Neutrophils
Point Mutation
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Messenger

Reverse Transcriptase Polymerase Chain Reaction

Superoxides

Source

Identifiers

PMID: 9781669
DOI: 10.1016/s0014-5793(98)01110-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9781669-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Enhanced fMLP-stimulated chemotaxis in human neutrophils from individuals carrying the G protein beta3 subunit 825 T-allele.PMID 9781669Read ↗

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