Article
G protein beta3 subunit 825T allele and enhanced coronary vasoconstriction on alpha(2)-adrenoceptor activation.
Circulation research - 12 Nov 1999
Baumgart D, Naber C, Haude M, Oldenburg O, Erbel R, Heusch G, Siffert W
Abstract excerpt
Recently, alpha(2)-adrenoceptor activation was shown to play an important role in the vasoconstriction of normal coronary arteries, whereas in the presence of atherosclerosis, the activation of both alpha(1)- and alpha(2)-adrenoceptors reduces coronary blood flow in humans. alpha(2)-Adrenoceptors activate pertussis toxin (PTX)-sensitive G proteins, whereas alpha(1)-adrenoceptors couple to PTX-insensitive G...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.