Molecular genetics of G proteins and atherosclerosis risk.

Abstract excerpt

Using a classical candidate gene approach, we have described a common C825T polymorphism in the gene GNB3 which encodes the ubiquitously expressed beta3 subunit of heterotrimeric G proteins. The 825T allele is associated with alternative splicing of the gene and the formation of a truncated but functionally active beta3 subunit which is referred to as Gbeta3s. Expression of the splice variant results in an...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Arteriosclerosis
• Share to GNB3 gene
• Share to Genetic Predisposition to Disease