Article
Enhanced epinephrine-induced platelet aggregation in individuals carrying the G protein beta3 subunit 825T allele.
FEBS letters - 10 Nov 2000
Naber C, Hermann B L, Vietzke D, Altmann C, Haude M, Mann K, Rosskopf D, Siffert W
Abstract excerpt
The 825T allele of a common C825T polymorphism in the gene encoding the beta3 subunit of heterotrimeric G proteins is associated with enhanced activation of pertussis toxin (PTX)-sensitive G proteins. We investigated responses of human platelets upon stimulation with epinephrine, which activates PTX-sensitive G proteins, and with agonists which activate additionally, or exclusively PTX-insensitive pathways....
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